Psychiatry Portal: Noon Conference

Drug doses & cirrhosis (12/1)

Noon Conference: December 1, 2020

Today we discussed a how cirrhosis impacts drug doses and adjustments, including benzos. 

Today's Post-Conference Reading articles:

1. Ferenci P, Litwin T, Seniow J, Czlonkowska A. Encephalopathy in Wilson disease: copper toxicity or liver failure? J Clin Exp Hepatol. 2015 Mar;5(Suppl 1):S88-95. doi: 10.1016/j.jceh.2014.09.002. Epub 2014 Sep 22. PMID: 26041965; PMCID: PMC4442862.
2. Weersink RA, Bouma M, Burger DM, Drenth JPH, Harkes-Idzinga SF, Hunfeld NGM, Metselaar HJ, Monster-Simons MH, Taxis K, Borgsteede SD. Evidence-Based Recommendations to Improve the Safe Use of Drugs in Patients with Liver Cirrhosis. Drug Saf. 2018 Jun;41(6):603-613. doi: 10.1007/s40264-017-0635-x. PMID: 29330714; PMCID: PMC5966501.
3. Lewis JH, Stine JG. Review article: prescribing medications in patients with cirrhosis - a practical guide. Aliment Pharmacol Ther. 2013 Jun;37(12):1132-56. doi: 10.1111/apt.12324. Epub 2013 May 3. PMID: 23638982.
4. LiverTox: Clinical and Research Information on DrugInduced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Benzodiazepines. [Updated 2017 Jan 24]. 

Additional Suggested Readings & Collections:

1. Drug dose adjustment in cirrhosis
2.